Defender Nathan Smith and midfielder Manny Oyeleke could be in contention for the home game against Salford City.
Smith has been self-isolating but could return to partner Leon Legge in Vale’s usual first-choice defensive pairing.
Meanwhile, influential midfielder Manny Oyeleke has recovered from injury but it will be up to Vale’s coaching staff whether they want to risk him or allow him more time to recover.
Definitely out are right-sided defender Zak Mills and James Gibbons with loanee Mitch Clark playing as right-back.
The Valiants could make changes to their starting eleven after the disappointing home loss to Carlisle. Tom Conlon and Luke Joyce will also be pushing for returns to the midfield.