The Sentinel reports that Tyler Walker could miss the rest of this season through injury.
Walker came on a substitute in the 1-1 draw with Bristol Rovers but was forced off with a suspected knee ligament injury.
The on loan Nottingham Forest youngster could now return to his parent club if he is unable to feature for the Valiants.
Interim Vale manager Michael Brown told the media: “We changed it and thought we would add some more pressure and put Tyler Walker up front… and he has gone off with a medial knee ligament.
“He has gone off and we might not see him again so this is where we are at the moment.”