Manager Neil Aspin has decided to bring in Billy Reeves, Cristian Montano, Marcus Harness and Tyrone Barnett for the Checkatrade Trophy game with Shrewsbury.
Goalkeeper Rob Lainton makes the bench.
The official Port Vale Twitter account confirmed the Vale team as:
Vale: Boot, Gunning, Anderson, Smith, Gibbons, Denton, Montano, Reeves, Pugh (C), Harness, Barnett
Subs: Lainton, Wilson, Kay, Kelly, Whitfield, Pope, Turner