Tom Pope scored against his former club as Micky Adams side shared the points with their South Cheshire rivals.
Adams handed full debuts to new signings Rob Kozluk and Liam Chilvers while Stuart Tomlinson, Doug Loft, Sam Morsy and Clayton McDonald also came back into the starting eleven.
Crewe took the lead when Byron Moore dribbled into the area and fired home past Stuart Tomlinson.
But Vale drew level when Rob Kozluk’s long throw found its way to Pope who slotted home, but neither side could find a winner in a frantic game.
Vale: Tomlinson, Kozluk (Yates), McDonald, Chilvers, Taylor, Griffith, Morsy (Little), Loft, Pope, Williamson (Rigg)
Subs: Martin, Dodds